Lee, Jae Hak Choi, Yong Hyun Lim, Yoo Jin Lee, Byoung Se Chi, Dae Yoon Jin, Changbae 2024-01-21T01:02:30Z 2024-01-21T01:02:30Z 2021-09-02 2007-05-15 0968-0896 https://pubs.kist.re.kr/handle/201004/134392 Five C2'-substituted 6-nitroquipazine (6-NQ) derivatives were prepared and evaluated in terms of their biological abilities (K) to displace [3 H]citalopram binding to serotonin transporter. The relationship between their structure and biological activities revealed that shorter alkyl groups tend to possess higher binding affinity. Both compounds 12a and 12c were found to have the equally highest binding affinity (K-i = 0.43 +/- 0.02 nM). (c) 2007 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD RAT 5-HYDROXYTRYPTAMINE INHIBITION SITES Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2 '-Substituted 6-nitroquipazines Article 10.1016/j.bmc.2007.03.001 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.15, no.10, pp.3499 - 3504 BIOORGANIC & MEDICINAL CHEMISTRY 15 10 3499 3504 scie scopus 000246257900021 2-s2.0-34047247853 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article RAT 5-HYDROXYTRYPTAMINE INHIBITION SITES serotonin transporter 6-nitroquipazine SAR 5-hydroxytryptamine