Park, Hee Sun Chung, Jin Wook Jae, Hwan Jun Kim, Young Il Son, Kyu Ri Lee, Min Jong Park, Jae Hyung Kang, Won Jun Coop, Jung Swan Chung, Hesson Lee, Kichang 2024-01-21T01:03:44Z 2024-01-21T01:03:44Z 2021-09-02 2007-05 1229-6929 https://pubs.kist.re.kr/handle/201004/134429 Objective: We wanted to investigate the feasibility of using FDG-PET for evaluating the antitumor effect of intraarterial administration of a hexokinase II inhibitor, 3-bromopyruvate (3-BrPA), in a rabbit VX2 liver tumor model. Materials and Methods: VX2 carcinoma was grown in the livers of ten rabbits. Two weeks later, liver CT was performed to confirm appropriate tumor growth for the experiment. After tumor volume-matched grouping of the rabbits, transcatheter intraarterial administration of 3-BrPA was performed (1 mM and 5 mM in five animals each, respectively). FDG-PET scan was performed the day before, immediately after and a Week after 3-BrPA administration. FDG uptake was semiquantified by measuring the standardized uptake value (SUV). A week after treatment, the experimental animals were sacrificed and the necrosis rates of the tumors were calculated based on the histopathology. Results: The SUV of the VX2 tumors before treatment (3.87 +/- 1.51 [mean +/- SD]) was significantly higher than that of nontumorous liver parenchyma (1.72 +/- 0.34) (p < 0.0001, Mann-Whitney U test). The SUV was significantly decreased immediately after 3-BrPA administration (2.05 +/- 1.21) (p = 0.002, Wilcoxon signed rank test). On the one-week follow up PET scan, the FDG uptake remained significantly lower (SUV 1.41 +/- 0.73) than that before treatment (p = 0.002), although three out of ten animals showed a slightly increasing tendency for the FDG uptake. The tumor necrosis rate ranged from 50.00% to 99.90% (85.48% +/- 15.87). There was no significant correlation between the SUV or the SUV decrease rate and the tumor necrosis rate in that range. Conclusion: Even though FDG-PET cannot exactly reflect the tumor necrosis rate, FDG-PET is a useful modality for the early assessment of the antitumor effect of intraarterial administration of 3-BrPA in VX2 liver tumor. English KOREAN RADIOLOGICAL SOC MITOCHONDRIAL BOUND HEXOKINASE HEPATOMA-CELL LINE HEPATOCELLULAR-CARCINOMA II HEXOKINASE GLUCOSE CATABOLISM CANCER-CELLS THERAPY EXPRESSION F-18 ATP FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model Article 10.3348/kjr.2007.8.3.216 1 KOREAN JOURNAL OF RADIOLOGY, v.8, no.3, pp.216 - 224 KOREAN JOURNAL OF RADIOLOGY 8 3 216 224 scie scopus kci ART001212440 000247670900006 2-s2.0-34249987354 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging Article II HEXOKINASE GLUCOSE CATABOLISM CANCER-CELLS THERAPY EXPRESSION F-18 ATP MITOCHONDRIAL BOUND HEXOKINASE HEPATOMA-CELL LINE HEPATOCELLULAR-CARCINOMA liver neoplasm, therapeutic radiology liver, interventional procedure liver, PET