Byeon, Seong Rim Lee, Ji Hoon Sohn, Ji-Hoon Kim, Dong Chan Shin, Kye Jung Yoo, Kyung Ho Mook-Jung, Inhee Lee, Won Koo Kim, Dong Jin 2024-01-21T01:06:40Z 2024-01-21T01:06:40Z 2021-08-31 2007-03-01 0960-894X https://pubs.kist.re.kr/handle/201004/134549 New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ALZHEIMERS-DISEASE AMYLOID HYPOTHESIS ALPHA-SYNUCLEIN PLAQUES MEDICINE CURCUMIN Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for A beta fibril formation Article 10.1016/j.bmcl.2006.10.090 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.5, pp.1466 - 1470 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 5 1466 1470 scie scopus 000244943300065 2-s2.0-33846931387 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ALZHEIMERS-DISEASE AMYLOID HYPOTHESIS ALPHA-SYNUCLEIN PLAQUES MEDICINE CURCUMIN A beta fibril formation inhibitor Alzheimer disease bis-styrylpyridine bis-styrylbenzene amyloid beta