Jeon, Heechol Jo, Nam Hyun Yoo, Kyung Ho Choi, Joung-Hoon Cho, Heeyeong Cho, Jung-Hyuck Oh, Chang-Hyun 2024-01-21T01:31:32Z 2024-01-21T01:31:32Z 2021-09-05 2007-03 0223-5234 https://pubs.kist.re.kr/handle/201004/134606 The synthesis of a new series of 1 beta-methylcarbapenems having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (IIIc) having methylaminosulfonamide moiety showed the most potent antibacterial activity. (c) 2006 Elsevier Masson SAS. All rights reserved. English ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER BETA-LACTAM ANTIBIOTICS CARBAPENEM ANTIBIOTICS THIENAMYCIN 1-BETA-METHYLCARBAPENEM DERIVATIVES Synthesis and antibacterial evaluation of 1 beta-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds Article 10.1016/j.ejmech.2006.10.006 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.42, no.3, pp.358 - 364 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 42 3 358 364 scie scopus 000245475900008 2-s2.0-33847417058 Chemistry, Medicinal Pharmacology & Pharmacy Article BETA-LACTAM ANTIBIOTICS CARBAPENEM ANTIBIOTICS THIENAMYCIN 1-BETA-METHYLCARBAPENEM DERIVATIVES 1 beta-methylcarbapenems antibacterial activity DHP-I stability