Shim, Woo Sun Kim, Jong-Ho Kim, Kwangmeyung Kim, Yoo-Shin Park, Rang-Woon Kim, In-San Kwon, Ick Chan Lee, Doo Sung 2024-01-21T01:32:19Z 2024-01-21T01:32:19Z 2021-09-05 2007-02-22 0378-5173 https://pubs.kist.re.kr/handle/201004/134638 Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX (c) 2006 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV CONTROLLED-RELEASE TRIBLOCK COPOLYMER DELIVERY-SYSTEM DRUG-RELEASE FORMULATION TAXOL PLGA ACID METASTASES LIPOSOMES pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel Article 10.1016/j.ijpharm.2006.09.027 1 INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.331, no.1, pp.11 - 18 INTERNATIONAL JOURNAL OF PHARMACEUTICS 331 1 11 18 scie scopus 000244634100002 2-s2.0-33846573824 Pharmacology & Pharmacy Pharmacology & Pharmacy Article CONTROLLED-RELEASE TRIBLOCK COPOLYMER DELIVERY-SYSTEM DRUG-RELEASE FORMULATION TAXOL PLGA ACID METASTASES LIPOSOMES pH/T-sensitive block copolymer hydrogel injectable hydrogel paclitaxel in vivo anti-tumor effect TUNEL assay