Jeon, Sun Ah Choo, Hyunah Park, Woo-Kyu Rhim, Hyewhon Ko, Soo Y. Cho, Yong Seo Koh, Hun Yeong Pae, Ae Nim 2024-01-21T01:32:23Z 2024-01-21T01:32:23Z 2021-09-04 2007-02-20 0253-2964 https://pubs.kist.re.kr/handle/201004/134641 The 5-HT6 antagonists are mainly related to the treatment of cognitive dysfunction or impairment associated with Alzheimer's disease and schizophrenia. There have been lots of efforts to develop 5-HT6 antagonists. As in our efforts, arylsulfonylpiperazine derivatives 1-3 were designed, synthesized and biologically evaluated against the human recombinant 5-HT6 serotonin receptor. Total 36 compounds were synthesized and the most active compound among the synthesized compounds is compound 2h with an IC50 value of 1.5 mu M. The compound 2h is novel as 5-HT6 receptor ligand and could act as lead for the novel 5-HT6 receptor ligands. English KOREAN CHEMICAL SOC SEROTONIN RECEPTORS ADENYLATE-CYCLASE STIMULATION BINDING Synthesis and biological evaluation of arylsulfonylpiperazine derivatives as 5-HT6 receptor ligands Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.28, no.2, pp.285 - 291 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 28 2 285 291 scie scopus kci ART001040889 000245197800025 2-s2.0-33847243659 Chemistry, Multidisciplinary Chemistry Article SEROTONIN RECEPTORS ADENYLATE-CYCLASE STIMULATION BINDING serotonin 5-HT6 receptor antagonists