Choo, Hyunah Beadle, James R. Chong, Youhoon Trahan, Julissa Hostetler, Karl Y. 2024-01-21T01:32:32Z 2024-01-21T01:32:32Z 2021-08-31 2007-02-15 0968-0896 https://pubs.kist.re.kr/handle/201004/134647 A new class of acyclic nucleoside phosphonates, the 5-phosphono-pent-2-en-1-yl nucleosides and their hexadecyloxypropyl esters, were synthesized from butyn-1-ol. Only the hexadecyloxypropyl esters showed antiviral activity against herpes simplex virus type 1. in vitro. Hexaclecyloxypropyl 1-(5-phosphono-pent-2-en-1-yl)-thymine was the most active and selective compound among the synthesized nucleotides with an EC50 value of 0.90 mu M. (c) 2006 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD HERPES-SIMPLEX-VIRUS ETHER LIPID ESTERS ORAL TREATMENT CIDOFOVIR CYTOMEGALOVIRUS ALKOXYALKYL INFECTIONS DRUGS Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates Article 10.1016/j.bmc.2006.11.038 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.15, no.4, pp.1771 - 1779 BIOORGANIC & MEDICINAL CHEMISTRY 15 4 1771 1779 scie scopus 000243983800020 2-s2.0-33847783139 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article HERPES-SIMPLEX-VIRUS ETHER LIPID ESTERS ORAL TREATMENT CIDOFOVIR CYTOMEGALOVIRUS ALKOXYALKYL INFECTIONS DRUGS antivirals nucleosides nucleoside phosphonates prodrugs