Kim, Hwa Sil Kim, Yoonjee Doddareddy, Munikumar Reddy Seo, Seon Hee Rhim, Hyewhon Tae, Jinsung Pae, Ae Nim Choo, Hyunah Cho, Yong Seo 2024-01-21T01:34:36Z 2024-01-21T01:34:36Z 2021-09-05 2007-01-15 0960-894X https://pubs.kist.re.kr/handle/201004/134733 A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium channel blocking activity with IC50 values of 0.93 and 0.96 mu M, respectively. (c) 2006 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CA2+ CHANNELS ETHOSUXIMIDE PAIN Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers Article 10.1016/j.bmcl.2006.10.042 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.2, pp.476 - 481 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 2 476 481 scie scopus 000244012200037 2-s2.0-33846104997 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article CA2+ CHANNELS ETHOSUXIMIDE PAIN T-type calcium channel blockers 1,3-dioxoisoindoline-5-carboxamides pharmacophore model