Kim, Aihong Hong, Joon Hee Oh, Chang Hyun 2024-01-21T02:01:30Z 2024-01-21T02:01:30Z 2021-09-02 2006-12 1525-7770 https://pubs.kist.re.kr/handle/201004/134872 A simple synthetic route for novel acyclic phosphonate nucleosides is described. The characteristic cyclopropyl moiety 8 was constructed employing the Simmons-Smith reaction as key step starting from simple acyclic 2-butene-1,4-diol. The condensation of the mesylate 11 with natural nucleosidic bases (A, C, T, U) under nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) and hydrolysis afforded the target nucleosides 16, 17, 18, and 19. In addition, the antiviral evaluations against various viruses were performed. English TAYLOR & FRANCIS INC ANTIVIRAL ACTIVITY MITSUNOBU REACTION ANALOGS DERIVATIVES POTENT AGENTS VIRUS Synthesis and anti-HCMV activity of novel cyclopropyl phosphonic acid nucleosides Article 10.1080/15257770600918920 1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.25, no.12, pp.1399 - 1406 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 25 12 1399 1406 scie scopus 000242214700007 2-s2.0-33750485342 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article ANTIVIRAL ACTIVITY MITSUNOBU REACTION ANALOGS DERIVATIVES POTENT AGENTS VIRUS antiviral agent cyclopropyl phosphonic acid nucleosides Simmons-Smith reaction