Kim, Jong-Hoon Cho, Soo Yeun Kang, Chang-Won Yoon, In-Soo Lee, Jun-Ho Jeong, Sang Min Lee, Byung-Hwan Lee, Joon-Hee Pyo, Mi-Kyung Choi, Sun-Hye Quan, Shi Fu Lee, Jong-Hwan Choi, Chi-Bong Rhim, Hyewhon Nah, Seung-Yeol 2024-01-21T02:02:18Z 2024-01-21T02:02:18Z 2021-09-01 2006-12 0918-6158 https://pubs.kist.re.kr/handle/201004/134906 Recent studies have shown that Panax ginseng has a variety of beneficial effects on the cardiovascular systems. Homocysteine (Hey), which is derived from L-methionine (Met), has been closely associated with the increased risk of cardiovascular diseases. In the present study, we examined whether in vivo long-term administration of ginseng saponins (GS), active ingredients of Panax ginseng, attenuate adverse vascular effects associated with chronic Met-induced hyperhomocysteinemia (H-Hey). We found that plasma Hey level, which was measured after 30 and 60 d, in GS (100 mg/kg) +Met co-administration group was significantly reduced when it was compared with Met alone treatment group. We could also observe the alleviation of endothelial damages of aortic artery vessels in GS (100 mg/kg)+Met co-administration group compared with Met alone treatment group. We compared aortic vasocontractile and vasodilatory responses between Met alone and GS (100 mg/kg)+Met co-treatment groups. We found that norepinephrine-induced vasocontractile responses were greatly decreased in GS (100 mg/kg)+Met co-treatment group and that carbachol-induced dilatory responses were greatly enhanced in GS (100 mg/kg)+Met co-administration groups as compared with Met alone treatment group. The present results indicate that in vivo long-term administration of GS attenuates adverse vascular effects associated with chronic Met-induced H-Hcy in rats. English PHARMACEUTICAL SOC JAPAN INDUCED ENDOTHELIAL DYSFUNCTION PORCINE CORONARY-ARTERIES NITRIC-OXIDE PANAX-GINSENG PROTOPANAXADIOL SAPONINS CARDIOVASCULAR-DISEASE COGNITIVE PERFORMANCE HYPERTENSIVE RATS FOLIC-ACID HOMOCYSTEINE Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia Article 10.1248/bpb.29.2425 1 BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.29, no.12, pp.2425 - 2431 BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 12 2425 2431 scie scopus 000243146400018 2-s2.0-33845352189 Pharmacology & Pharmacy Pharmacology & Pharmacy Article INDUCED ENDOTHELIAL DYSFUNCTION PORCINE CORONARY-ARTERIES NITRIC-OXIDE PANAX-GINSENG PROTOPANAXADIOL SAPONINS CARDIOVASCULAR-DISEASE COGNITIVE PERFORMANCE HYPERTENSIVE RATS FOLIC-ACID HOMOCYSTEINE Panax ginseng Ginseng saponin methionine hyperhomocysteinemia vascular dysfunction