Kim, Sang-Heon Kwon, Jae Hyun Chung, Min Sub Chung, Eunna Jung, Youngmee Kim, Soo Hyun Kim, Young Ha 2024-01-21T02:04:16Z 2024-01-21T02:04:16Z 2021-09-02 2006-11 0920-5063 https://pubs.kist.re.kr/handle/201004/134987 Biodegradable macroporous scaffolds have been developed for tissue-engineering applications. We fabricated and characterized a new tubular, macroporous, fibrous scaffold using a very elastic biodegradable co-polymer, poly(L-lactide-co-caprolactone) (PLCL, 5:5) in a gel-spinning process. A viscous PLCL solution was spun as a gel-phase under swirl-flow conditions and was subsequently fabricated to produce a tubular fibrous scaffold on a rotating cylindrical shaft in a methanol solution. The porosity and median pore size of the fibrous PLCL scaffolds were 55-75% and 120-150 mu m, respectively, using a 5-10% PLCL solution. The use of a 7.5% (w/v) solution resulted in scaffolds with tensile strength and elastic modulus of 3.39 MPa and 1.22 MPa, respectively. The scaffolds exhibited 500-600% elongation-at-break. The tensile strength and modulus of fibrous PLCL scaffolds were proven to decrease on lowering the concentration of the PLCL spinning solution; however, the tensile strength and modulus of fibrous PLCL scaffolds, produced from 5% solutions, are approximately 4-and 5-times higher than those of extruded PLCL scaffolds. These properties indicated that the fibrous PLCL scaffolds were very elastic and mechanically strong. The scaffolds appeared to be well interconnected between the pores as determined by SEM imaging analysis. In addition, the cell-seeding efficiency was 2-fold higher using gel-spun scaffolds than using extruded scaffolds. These results suggest that the gel-spun fibrous PLCL scaffold is an excellent matrix for vascular tissue-engineering applications. English TAYLOR & FRANCIS LTD IN-VITRO FOAMS CELL MANUFACTURE DEGRADATION COPOLYMERS NANOFIBER MATRIX Fabrication of a new tubular fibrous PLCL scaffold for vascular tissue engineering Article 10.1163/156856206778937244 1 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.17, no.12, pp.1359 - 1374 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 17 12 1359 1374 scie scopus 000243447100003 2-s2.0-33845255014 Engineering, Biomedical Materials Science, Biomaterials Polymer Science Engineering Materials Science Polymer Science Article IN-VITRO FOAMS CELL MANUFACTURE DEGRADATION COPOLYMERS NANOFIBER MATRIX poly(L-lactide-co-caprolactone) gel spinning fibrous scaffold vascular tissue engineering