Hwang, Kyo Seon Eom, Kilho Lee, Jeong Hoon Chun, Dong Won Cha, Byung Hak Yoon, Dae Sung Kim, Tae Song Park, Jung Ho 2024-01-21T02:05:03Z 2024-01-21T02:05:03Z 2021-09-01 2006-10-23 0003-6951 https://pubs.kist.re.kr/handle/201004/135019 Nanomechanical microcantilevers have played a vital role in detecting biomolecular interactions. The ability of microcantilevers to detect biomolecular interactions is ascribed to the principle that the surface stress, caused by biomolecular interactions, dominates the dynamical response of the microcantilever. Here we have experimentally studied the correlation between biomolecular interactions and the dynamical response of microcantilevers. Moreover, the authors employed a mechanical beam model to calculate the surface stress, representing the biomolecular interactions, through measuring the resonant frequency shift. The quantitative analysis of surface stress, driven by the specific protein-protein interactions, demonstrated that microcantilevers enable the quantitative study of biomolecular interactions. (c) 2006 American Institute of Physics. English AMER INST PHYSICS RESONANT-FREQUENCY SHIFT C-REACTIVE PROTEIN LABEL-FREE CANTILEVER MASS Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers Article 10.1063/1.2372700 1 APPLIED PHYSICS LETTERS, v.89, no.17 APPLIED PHYSICS LETTERS 89 17 scie scopus 000241585800141 2-s2.0-33750461230 Physics, Applied Physics Article RESONANT-FREQUENCY SHIFT C-REACTIVE PROTEIN LABEL-FREE CANTILEVER MASS microcantilever surface stress dynamic response nanomechanics