Lee, Jae Yeol Park, Seong Jun Park, Sung Jun Lee, Min Joo Rhim, Hyewhon Seo, Seon Hee Kim, Ki-Sun 2024-01-21T02:05:33Z 2024-01-21T02:05:33Z 2021-09-01 2006-10-01 0960-894X https://pubs.kist.re.kr/handle/201004/135039 This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range. (c) 2006 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CA2+ ENTRY PROLIFERATION CYCLE Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers Article 10.1016/j.bmcl.2006.07.046 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.16, no.19, pp.5014 - 5017 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16 19 5014 5017 scie scopus 000240615400006 2-s2.0-33747334641 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article CA2+ ENTRY PROLIFERATION CYCLE cancer cell growth inhibition T-type calcium channel blockers cisplatin