Oh, Chang Hyun Hong, Joon Hee 2024-01-21T02:32:53Z 2024-01-21T02:32:53Z 2021-09-01 2006-09 0365-6233 https://pubs.kist.re.kr/handle/201004/135195 Novel phenyl-branched cyclopropyl nucleosides, phosphonates, and phosphonic acid analogues were designed and synthesized as potential antiviral agents. Coupling of the mesylate 10 with natural bases (U, T, C, A) and desilylation/hydrolysis afforded a series of novel cyclopropyl nucleosides 15-18. Phosphonate and phosphonic acid nucleosides 22-29 were also readily synthesized from the mesylate 21. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2, and HCMV. English WILEY-V C H VERLAG GMBH ACYCLIC NUCLEOSIDES PRODRUGS ANALOGS Synthesis and antiviral evaluation of novel cyclopropyl nucleosides, phosphonate nucleosides and phosphonic acid nucleosides Article 10.1002/ardp.200600031 1 ARCHIV DER PHARMAZIE, v.339, no.9, pp.507 - 512 ARCHIV DER PHARMAZIE 339 9 507 512 scie scopus 000240793200003 2-s2.0-33749573167 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article ACYCLIC NUCLEOSIDES PRODRUGS ANALOGS antiviral agents branched nucleoside cyclopropyl nucleoside, phosphonate nucleoside phosphonic acid nucleoside