Lee, Ki Yong Nam, Dong Hyuk Moon, Chang Sang Seo, Seon Hee Lee, Jae Yeol Lee, Yon Sun 2024-01-21T02:35:09Z 2024-01-21T02:35:09Z 2021-09-01 2006-08 0223-5234 https://pubs.kist.re.kr/handle/201004/135289 2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds 3a-g having structural features of styrylehromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds 3a-g were synthesized by the condensation of 2-methylchromone derivative 7 with several aromatic aldehydes. Among synthesized, compound 3e showed the significant cytotoxic activity on HCT-15 cell line with IC50 values of 7.17 mu g/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application. (c) 2006 Elsevier SAS. All rights reserved. English ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER HORMOTHAMNIONE Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents Article 10.1016/j.ejmech.2006.04.008 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.41, no.8, pp.991 - 996 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 41 8 991 996 scie scopus 000240213700010 2-s2.0-33747001295 Chemistry, Medicinal Pharmacology & Pharmacy Article HORMOTHAMNIONE styrylchromone arylethenylehromone lavendustin A cytotoxicity HCT-15