Joe, Min-Jeong Kim, Su-Nam Choi, Hye-Young Shin, Woon-Seob Park, Gab-Man Kang, Dong-Won Kim, Yong Kee 2024-01-21T02:35:25Z 2024-01-21T02:35:25Z 2021-09-01 2006-08 0918-6158 https://pubs.kist.re.kr/handle/201004/135300 In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-kappa B and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-kappa B and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging. English PHARMACEUTICAL SOC JAPAN IRRADIATED HUMAN SKIN KUROME OKAMURA VITAMIN-C KAPPA-B MECHANISMS TRANSCRIPTION COLLAGENASE GENE PHLOROTANNINS INTEGRATION The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts Article 10.1248/bpb.29.1735 1 BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.29, no.8, pp.1735 - 1739 BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 8 1735 1739 scie scopus 000240053500038 2-s2.0-33746773084 Pharmacology & Pharmacy Pharmacology & Pharmacy Article IRRADIATED HUMAN SKIN KUROME OKAMURA VITAMIN-C KAPPA-B MECHANISMS TRANSCRIPTION COLLAGENASE GENE PHLOROTANNINS INTEGRATION Ecklonia stolonifera eckol dieckol matrix metalloproteinase (MMP)-I NF-kappa B AP-1