Noh, Eun Jung Ahn, Kwang Seok Shin, Eun Myoung Jung, Sang Hoon Kim, Yeong Shik 2024-01-21T02:36:17Z 2024-01-21T02:36:17Z 2021-09-01 2006-07-10 0024-3205 https://pubs.kist.re.kr/handle/201004/135333 Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus. We investigated the anti-inflanimatory properties of dehydroevodiamine in RAW 264.7 murine macrophages. The results indicated that dehydroevodiamine inhibited the expression of LPS-induced NOS and COX-2 proteins and suppressed also their mRNAs from RT-PCR experiment on RAW 264.7 cells. Furthermore, this compound inhibited the level of LPS-stimulated prostaglandin E-2 (PGE(2)) and LPS-induced nuclear factor-kappa B (NF-kappa B). Therefore, we suggested that the effect of dehydroevodiamine-mediated inhibition of the expression LPS-induced NOS and COX-2 genes is due to under the suppression of NF-kappa B activation in the transcriptional level. (c) 2006 Elsevier Inc. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD NITRIC-OXIDE SYNTHASE NECROSIS-FACTOR-ALPHA NUCLEAR-FACTOR TRANSCRIPTION FACTOR PHORBOL ESTER UP-REGULATION HUMAN HACAT CELLS GENE EVODIAMINE Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappa B activation in RAW 264.7 macrophages Article 10.1016/j.lfs.2006.02.020 1 LIFE SCIENCES, v.79, no.7, pp.695 - 701 LIFE SCIENCES 79 7 695 701 scie scopus 000238873500012 2-s2.0-33745287157 Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine Pharmacology & Pharmacy Article NITRIC-OXIDE SYNTHASE NECROSIS-FACTOR-ALPHA NUCLEAR-FACTOR TRANSCRIPTION FACTOR PHORBOL ESTER UP-REGULATION HUMAN HACAT CELLS GENE EVODIAMINE dehydroevodiamine prostaglandins E-2 inducible nitric oxide synthase cyclooxygenase-2 nuclear factor-kappa B