Oh, Chang Hyun Kim, Jin Woo Hong, Joon Hee 2024-01-21T03:00:29Z 2024-01-21T03:00:29Z 2021-09-02 2006-07 1525-7770 https://pubs.kist.re.kr/handle/201004/135359 Novel vinyl branched apiosyl nucleosides were synthesized in this study. Apiosyl sugar moiety was constructed by sequential ozonolysis and reductions. The bases (uracil and thymine) were efficiently coupled by glycosyl condensation procedure (persilyated base and TMSOTf). The antiviral activities of the synthesized compounds were evaluated against the HIV-1, HSV-1, HSV-2, and HCMV. Compound 10 beta displayed moderate anti-HIV activity (EC50 = 17.3 mu g/mL) without exhibiting any cytotoxicity up to 100 mu M. English TAYLOR & FRANCIS INC IMMUNODEFICIENCY POTENT Simple synthesis and anti-HIV activity of novel 3'-vinyl branched apiosyl pyrimidine nucleosides Article 10.1080/15257770600793869 1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.25, no.8, pp.871 - 878 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 25 8 871 878 scie scopus 000239453200005 2-s2.0-33746826080 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article IMMUNODEFICIENCY POTENT antiviral agents apiosyl nucleoside ozonolysis