Lee, Sang Hee Jung, Byung Hwa Kim, Sun Yeou Lee, Eunjoo H. Chung, Bong Chul 2024-01-21T03:00:37Z 2024-01-21T03:00:37Z 2021-09-01 2006-07 1043-6618 https://pubs.kist.re.kr/handle/201004/135365 The present study aims to demonstrate the ability of ginseng total saponin (GTS), ginsenosides Rg3 and Rb1 to reduce brain polyamine levels in immobilization-stressed gerbil mice. A previous study reported that ginsenosides had an anti-stress property. So, we tested the anti-stress effect of ginseng by investigating the brain level of polyamine, a well-known stress stimuli marker. We determined the brain polyamine levels under 30-min immobilization stress in pretreating GTS (100 mg kg(-1), oral), ginsenosides Rg3 and Rb1 (10 mg kg(-1), oral, respectively). Then, we compared polyarnine levels between the non-stressed mouse and the stressed mouse which had taken saline orally to check the placebo effect. Putrescine (PUT) levels were significantly increased (P < 0.01) in the stressed condition, but it was reduced in pretreatment of GTS, ginsenosides Rg3 (P < 0.01, respectively) and Rbl (P < 0.001) under 30-min immobilization stressed-mouse. However, other polyamine levels did not change regardless of stressed condition or GTS-, ginsenosides Rg3- and Rb1-treated stressed condition. These results mean that only PUT could be a marker for stress and GTS, ginsenosides Rg3 and Rbl administration lead to an anti-stress effect. Thus, our studies indicate that GTS, ginsenosides Rg3 and Rbl may play a neuroprotective role in the immobilization-stressed brain. (c) 2006 Published by Elsevier Ltd. English ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD RAT PLASMA RB-1 NEURODEGENERATION NEUROSTEROIDS GLUTAMATE CELLS MODEL MICE The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress Article 10.1016/j.phrs.2006.02.001 1 PHARMACOLOGICAL RESEARCH, v.54, no.1, pp.46 - 49 PHARMACOLOGICAL RESEARCH 54 1 46 49 scie scopus 000238867000008 2-s2.0-33744944294 Pharmacology & Pharmacy Pharmacology & Pharmacy Review RAT PLASMA RB-1 NEURODEGENERATION NEUROSTEROIDS GLUTAMATE CELLS MODEL MICE immobilization stress brain polyamine ginseng total saponin (GTS) ginsenosides Rg3 and Rb1