Cho, Jung-Hyuck Ahn, Soo-Hyun Jeon, Heechol Kim, So Young Oh, Chang-Hyun 2024-01-21T03:04:04Z 2024-01-21T03:04:04Z 2022-01-10 2006-05-20 0253-2964 https://pubs.kist.re.kr/handle/201004/135504 The synthesis of a new series of 1 beta-methylcarbapenems having 5-(1,2-disubstituted ethyl)pyrrolidine moiety are described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Among them, compound (IIIc) having 1-methoxyimino-2-hydroxyethyl moiety showed the most potent antibacterial activity. English WILEY-V C H VERLAG GMBH BETA-LACTAM ANTIBIOTICS CARBAPENEM ANTIBIOTICS THIENAMYCIN 1-BETA-METHYLCARBAPENEM Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(1,2-disubstituted ethyl)-pyrrolidin-3-ylthio]carbapenem derivatives. Part III Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.27, no.5, pp.705 - 712 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 27 5 705 712 scie scopus kci ART001185444 000238241700016 2-s2.0-33744465244 Chemistry, Multidisciplinary Chemistry Article BETA-LACTAM ANTIBIOTICS CARBAPENEM ANTIBIOTICS THIENAMYCIN 1-BETA-METHYLCARBAPENEM 1 beta-methylcarbapenem antibacterial activity substituent effect