Kim, HJ Kim, EJ Seo, SH Shin, CG Jin, C Lee, YS 2024-01-21T03:31:11Z 2024-01-21T03:31:11Z 2021-09-01 2006-04 0163-3864 https://pubs.kist.re.kr/handle/201004/135627 Bioassay-directed chromatographic fractionation of an ethyl acetate extract of Gardenia jasminoides (Gardeniae Fructus) afforded a new vanillic acid 4-O-beta-D-(6'-sinapoyl)glucopyranoside (1) and five new quinic acid derivatives, methyl 5-O-caffeoyl-3-O-sinapoylquinate (2), ethyl 5-O-caffeoyl-3-O-sinapoylquinate (3), methyl 5-O-caffeoyl-4-O-sinapoylquinate (4), ethyl 5-O-caffeoyl-4-O-sinapoylquinate (5), and methyl 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinate (6), together with three known quinic acid derivatives, two flavonoids, two iridoids, and two phenolic compounds. The structures of new compounds were elucidated by the aid of spectroscopic methods. These compounds were assessed for antioxidant activity using three different cell-free bioassay systems and for HIV-1 integrase inhibitory activity. Five new quinic acid derivatives showed potent DPPH radical scavenging, superoxide anion scavenging, and lipid peroxidation inhibition activities. These new quinic acid derivatives also exhibited HIV-1 integrase inhibitory activity. English AMER CHEMICAL SOC IMMUNODEFICIENCY-VIRUS TYPE-1 CONSTITUENTS IDENTIFICATION FLAVONOIDS INHIBITORS INTEGRASE ANALOGS Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus Article 10.1021/np050447r 1 JOURNAL OF NATURAL PRODUCTS, v.69, no.4, pp.600 - 603 JOURNAL OF NATURAL PRODUCTS 69 4 600 603 scie scopus 000237343400016 2-s2.0-33744479984 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article IMMUNODEFICIENCY-VIRUS TYPE-1 CONSTITUENTS IDENTIFICATION FLAVONOIDS INHIBITORS INTEGRASE ANALOGS Gardenia jasminoides vanillic acid sinapoylglucoside quinic acid derivatives antioxidants HIV-1 integrase