Lee, YS Park, JH Kim, MH Seo, SH Kim, HJ 2024-01-21T03:36:12Z 2024-01-21T03:36:12Z 2021-09-02 2006-03 0365-6233 https://pubs.kist.re.kr/handle/201004/135728 Kojic acid derivative 2 was synthesized by joining two pyrone rings through an ethylene linkage by Horner-Emmons reaction of phosphonate 6 with aldehyde 7. The intermediates 6 and 7 were derived from kojic acid. The tyrosinase inhibitory activity of 2 was about 8 times more potent (IC50 = 3.63 mu M) than that of kojic acid (IC50 = 30.61 mu M). Compound 2 also exhibited potent melanin synthesis inhibitory activity (19.53% inhibition at 5 mu g) indicating that the connection of two pyrone rings of kojic acid through a suitable linker can be an useful strategy for identification of potent tyrosinase inhibitiors. English WILEY-V C H VERLAG GMBH AMINO-ACID PIGMENTATION Synthesis of tyrosinase inhibitory kojic acid derivative Article 10.1002/ardp.200500213 1 ARCHIV DER PHARMAZIE, v.339, no.3, pp.111 - 114 ARCHIV DER PHARMAZIE 339 3 111 114 scie scopus 000236505200001 2-s2.0-33645981637 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article AMINO-ACID PIGMENTATION tyrosinase inhibitor kojic acid melanin production skin-whitening