Jung, SH Park, SY Kim-Pak, Y Lee, HK Park, KS Shin, KH Ohuchi, K Shin, HK Keum, SR Lim, SS 2024-01-21T03:36:24Z 2024-01-21T03:36:24Z 2021-09-02 2006-03 0009-2363 https://pubs.kist.re.kr/handle/201004/135732 Fifteen chalcones and three thiazolidinedione (TZD) chalcones were prepared to evaluate their peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand-binding activities. Among the three TZDs, one compound possessed PPAR-gamma transactivation potential, while the others showed antagonistic activity against PPAR-gamma transactivation. Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4' or 5' in chalcone plays a key role in determining the potency of PPAR-gamma activation. English PHARMACEUTICAL SOC JAPAN HYPOGLYCEMIC ACTIVITY FLAVONE DERIVATIVES ALDOSE REDUCTASE CHALCONES ADIPOCYTES TARGETS TISSUES Synthesis and PPAR-gamma ligand-binding activity of the new series of 2 '-hydroxychalcone and thiazolidinedione derivatives Article 10.1248/cpb.54.368 1 CHEMICAL & PHARMACEUTICAL BULLETIN, v.54, no.3, pp.368 - 371 CHEMICAL & PHARMACEUTICAL BULLETIN 54 3 368 371 scie scopus 000236227000018 2-s2.0-33645217958 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article HYPOGLYCEMIC ACTIVITY FLAVONE DERIVATIVES ALDOSE REDUCTASE CHALCONES ADIPOCYTES TARGETS TISSUES PPAR-gamma 2 &apos ,5 &apos -dihydroxy-4-methoxychalcone chalconyl-thiazolidinedione