Ahn, SH Jeon, H Choi, JH Baek, D Seo, SH Cho, JH Oh, CH 2024-01-21T03:39:45Z 2024-01-21T03:39:45Z 2021-09-02 2006-02 0365-6233 https://pubs.kist.re.kr/handle/201004/135789 The synthesis of a new series of 1 beta-methylcarbapenems having a 5-(1,2-disubstituted ethyl) pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the pyrrolidine ring was investigated. A particular compound IIIf having a 1-methoxyimino-2-carbamoylethyl substituted moiety showed the most potent antibacterial activity. English WILEY-V C H VERLAG GMBH Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(1,2-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem derivatives Article 10.1002/ardp.200500139 1 ARCHIV DER PHARMAZIE, v.339, no.2, pp.67 - 73 ARCHIV DER PHARMAZIE 339 2 67 73 scie scopus 000235783200002 2-s2.0-33144469140 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article 1 beta-methylcarbapenem antibacterial activity substituent effect