Park, JH Kwon, S Lee, M Chung, H Kim, JH Kim, YS Park, RW Kim, IS Seo, SB Kwon, IC Jeong, SY 2024-01-21T03:42:57Z 2024-01-21T03:42:57Z 2021-09-02 2006-01 0142-9612 https://pubs.kist.re.kr/handle/201004/135852 Self-assembled nanoparticles, formed by polymeric amphiphiles, have been demonstrated to accumulate in solid tumors by the enhanced permeability and retention effect, following intravenous administration. In this study, hydrophobically modified glycol chitosans capable of forming nano-sized self-aggregates were prepared by chemical conjugation of fluorescein isothiocyanate or doxorubicin to the backbone of glycol chitosan. Biodistribution of self-aggregates (300 mu in diameter) was evaluated using tissues obtained from tumor-bearing mice, to which self-aggregates were systemically administered via the tail vein. Irrespective of the dose, a negligible quantity of self-aggregates was found in heart and lung, whereas a small amount (3.6-3.8% of dose) was detected in liver for 3 days after intravenous injection of self-aggregates. The distributed amount of self-aggregates gradually increased in tumor as blood circulation time increased. The concentration of self-aggregates in blood was as high as 14% of dose at 1 day after intravenous injection and was still higher than 8% even at 3 days. When self-aggregates loaded with doxorubicin were administered into the tumor-bearing mice via the tail vein, they exhibited lower toxicity than but comparable anti-tumor activity to free doxorubicin. These results revealed the promising potential of self-aggregates on the basis of glycol chitosan as a carrier for hydrophobic antitumor agents. (c) 2005 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD ACID-MODIFIED CHITOSAN WATER-SOLUBLE CHITOSAN HUMAN TUMOR XENOGRAFT GENE DELIVERY-SYSTEM MICELLAR CHARACTERISTICS 5-BETA-CHOLANIC ACID COPOLYMER MICELLES DRUG-DELIVERY PERMEABILITY DERIVATIVES Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: In vivo biodistribution and anti-tumor activity Article 10.1016/j.biomaterials.2005.05.028 1 BIOMATERIALS, v.27, no.1, pp.119 - 126 BIOMATERIALS 27 1 119 126 scie scopus 000232460800014 2-s2.0-24044459756 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article ACID-MODIFIED CHITOSAN WATER-SOLUBLE CHITOSAN HUMAN TUMOR XENOGRAFT GENE DELIVERY-SYSTEM MICELLAR CHARACTERISTICS 5-BETA-CHOLANIC ACID COPOLYMER MICELLES DRUG-DELIVERY PERMEABILITY DERIVATIVES drug delivery glycol chitosan nanoparticle self-assembly