Kim, Y Jun, M Lee, W 2024-01-21T03:43:09Z 2024-01-21T03:43:09Z 2021-09-02 2006-01 0951-4198 https://pubs.kist.re.kr/handle/201004/135856 Boldione (1,4-androstadiene-3,17-dione) is a direct precursor (prohormone) to the anabolic steroid boldenone (1,4-androstadiene-17 beta-ol-3-one). It is advertised as a highly anabolic/androgenic compound promoting muscularity, enhancing strength and overall physical performance, and is available on the Internet and in health stores. This work was undertaken to determine and characterize boldione and its metabolites in human urine, using both liquid chromatography with electrospray ionization mass spectrometry and gas chromatography with mass spectrometry and derivatization. Boldione and its three metabolites were detected in dosed human urine after dosing a healthy volunteer with 100mg boldione. The excretion studies showed that boldione and its metabolites were detectable in urine for 48 h after oral administration, with maximum excretion rates after 1.8 and 3.6 h (boldenone case). The amounts of boldione and boldenone excreted in urine from this 100 mg dose were 34.45 and 15.95 mg, respectively. Copyright (c) 2005 John Wiley & Sons, Ltd. English JOHN WILEY & SONS LTD ANABOLIC-STEROID METABOLITES IDENTIFICATION BOLDENONE CATTLE FECES Characterization of boldione and its metabolites in human urine by liquid chromatography/electrospray ionization mass spectrometry and gas chromatography/mass spectrometry Article 10.1002/rcm.2271 1 RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v.20, no.1, pp.9 - 20 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 20 1 9 20 scie scopus 000234159300003 2-s2.0-29144462641 Biochemical Research Methods Chemistry, Analytical Spectroscopy Biochemistry & Molecular Biology Chemistry Spectroscopy Article ANABOLIC-STEROID METABOLITES IDENTIFICATION BOLDENONE CATTLE FECES Bodione Metabolites Determination charaterization