Bae, S Hahn, HG Nam, Kee Dal 2024-01-21T04:08:50Z 2024-01-21T04:08:50Z 2021-09-02 2005-11 1520-4766 https://pubs.kist.re.kr/handle/201004/136028 We have developed combinatorial libraries of new 1,3-imidazoline-2-thiones 5 and 2-phenylimino-1,3thiazolines 7 by way of different reaction sequences of the same three components, gamma-chloroacetoacetanilides 1, amines 2, and isothiocyanates 3 in a parallel synthetic fashion. One of the building blocks, the gamma-chloroacetoacetanilides 1, was prepared by the sequential reaction of 4-methylene-oxetan-2-one (ketene dimer) with chlorine and various anilines. The condensation of 1 with amines gave dihydrofuran 4 intermediates that when reacted with 3 afforded the 1,3-imidazoline-2-thiones 5. On the other hand, reaction of 3 with 2 provided substituted thioureas 6 that were reacted with 1 to yield 2-phenylimino-1,3-thiazolines 7. English AMER CHEMICAL SOC SOLID-PHASE SYNTHESIS CLICK CHEMISTRY HETEROCYCLIC SYNTHESIS DERIVATIVES Syntheses of 1,3-imidazoline-2-thione and 2-phenylimino-1,3-thiazoline combinatorial libraries through different sequences of the same components Article 10.1021/cc049811f 1 JOURNAL OF COMBINATORIAL CHEMISTRY, v.7, no.6, pp.826 - 836 JOURNAL OF COMBINATORIAL CHEMISTRY 7 6 826 836 scie scopus 000233352800009 2-s2.0-28244495584 Chemistry, Applied Chemistry, Medicinal Chemistry, Multidisciplinary Chemistry Pharmacology & Pharmacy Article SOLID-PHASE SYNTHESIS CLICK CHEMISTRY HETEROCYCLIC SYNTHESIS DERIVATIVES synthesis combinatorial chemical library agrochemical fungicide 1,3-imidazoline-2-thione 2-phenylimino-1,3-thiazoline