Ishikawa, T Kaneko, M Shin, HS Takahashi, T 2024-01-21T04:10:35Z 2024-01-21T04:10:35Z 2021-09-03 2005-10-01 0022-3751 https://pubs.kist.re.kr/handle/201004/136061 At the nerve terminal, both N- and P/Q-type Ca2+ channels mediate synaptic transmission, with their relative contribution varying between synapses and with postnatal age. To clarify functional significance of different presynaptic Ca2+ channel subtypes, we recorded N-type and P/Q-type Ca2+ currents directly from calyces of Held nerve terminals in alpha(1A)-subunit-deficient mice and wild-type (WT) mice, respectively. The most prominent feature of P/Q-type Ca2+ currents was activity-dependent facilitation, which was absent for N-type Ca2+ currents. EPSCs mediated by P/Q-type Ca2+ currents showed less depression during high-frequency stimulation compared with those mediated by N-type Ca2+ currents. In addition, the maximal inhibition by the GABA(B) receptor agonist baclofen was greater for EPSCs mediated by N-type channels than for those mediated by P/0-type channels. These results suggest that the developmental switch of presynaptic Ca2+ channels from N- to P/Q-type may serve to increase synaptic efficacy at high frequencies of activity, securing high-fidelity synaptic transmission. English WILEY SHORT-TERM DEPRESSION GTP-BINDING PROTEIN CALCIUM-CHANNELS TRANSMITTER RELEASE DEVELOPMENTAL-CHANGES ADENOSINE A(1) CURRENTS FACILITATION INHIBITION MODULATION Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of held of mice Article 10.1113/jphysiol.2005.089912 1 JOURNAL OF PHYSIOLOGY-LONDON, v.568, no.1, pp.199 - 209 JOURNAL OF PHYSIOLOGY-LONDON 568 1 199 209 scie scopus 000232474900018 2-s2.0-26844476796 Neurosciences Physiology Neurosciences & Neurology Physiology Article SHORT-TERM DEPRESSION GTP-BINDING PROTEIN CALCIUM-CHANNELS TRANSMITTER RELEASE DEVELOPMENTAL-CHANGES ADENOSINE A(1) CURRENTS FACILITATION INHIBITION MODULATION