Kim, P Kim, DH Kim, B Choi, SK Lee, SH Khademhosseini, A Langer, R Suh, KY 2024-01-21T04:12:16Z 2024-01-21T04:12:16Z 2021-09-03 2005-10 0957-4484 https://pubs.kist.re.kr/handle/201004/136093 A simple method was developed to fabricate polyethylene glycol (PEG) nanostructures using capillary lithography mediated by ultraviolet (UV) exposure. Acrylate-containing PEG monomers, such as PEG dimethacrylate (PEG-DMA, MW = 330), were photo-cross-linked under UV exposure to generate patterned structures. In comparison to unpatterned PEG films, hydrophobicity of PEG nanostructure modified surfaces was significantly enhanced. This could be attributed to trapped air in the nanostructures as supported by water contact angle measurements. Proteins (fibronectin, immunoglobulin, and albumin) and cells (fibroblasts and P19 EC cells) were examined on the modified surfaces to test for the level of protein adsorption and cell adhesion. It was found that proteins and cells preferred to adhere on nanostructured PEG surfaces in comparison to unpatterned PEG films; however, this level of adhesion was significantly lower than that of glass controls. These results suggest that capillary lithography can be used to fabricate PEG nanostructures capable of modifying protein and cell adhesive properties of surfaces. English IOP PUBLISHING LTD SELF-ASSEMBLED MONOLAYERS SOFT LITHOGRAPHY MAMMALIAN-CELLS MICROSTRUCTURES MOLD STABILITY SURFACES PATTERN BIOLOGY FILMS Fabrication of nanostructures of polyethylene glycol for applications to protein adsorption and cell adhesion Article 10.1088/0957-4484/16/10/072 1 NANOTECHNOLOGY, v.16, no.10, pp.2420 - 2426 NANOTECHNOLOGY 16 10 2420 2426 scie scopus 000232906200073 2-s2.0-25444449794 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Science & Technology - Other Topics Materials Science Physics Article SELF-ASSEMBLED MONOLAYERS SOFT LITHOGRAPHY MAMMALIAN-CELLS MICROSTRUCTURES MOLD STABILITY SURFACES PATTERN BIOLOGY FILMS