Kim, EC Min, JK Kim, TY Lee, SJ Yang, HO Han, S Kim, YM Kwon, YG 2024-01-21T04:13:56Z 2024-01-21T04:13:56Z 2021-09-03 2005-09-23 0006-291X https://pubs.kist.re.kr/handle/201004/136123 [6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has anti-bacterial, anti-inflammatory, and anti-tumor-promoting activities. Here, we describe its novel anti-angiogenic activity in vitro and in vivo. In vitro, [6]-gingerol inhibited both the VEGF- and bFGF-induced proliferation of human endothelial cells and caused cell cycle arrest in the G1 phase. It also blocked capillary-like tube formation by endothelial cells in response to VEGF, and strongly inhibited sprouting of endothelial cells in the rat aorta and formation of new blood vessel in the mouse cornea in response to VEGF. Moreover, i.p. administration, without reaching tumor cytotoxic blood levels, to mice receiving i.v. injection of B16F10 melanoma cells, reduced the number of lung metastasis, with preservation of apparently healthy behavior. Taken together, these results demonstrate that [6]gingerol inhibits angiogenesis and may be useful in the treatment of tumors and other angiogenesis-dependent diseases. (c) 2005 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE MOLECULAR-MECHANISMS TUMOR VASCULATURE ENDOTHELIAL-CELLS CANCER PREVENTION QUERCETIN THERAPY DISEASE DIETARY GROWTH [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo Article 10.1016/j.bbrc.2005.07.076 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.335, no.2, pp.300 - 308 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 335 2 300 308 scie scopus 000231586600006 2-s2.0-23744431584 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article MOLECULAR-MECHANISMS TUMOR VASCULATURE ENDOTHELIAL-CELLS CANCER PREVENTION QUERCETIN THERAPY DISEASE DIETARY GROWTH [6]-gingerol VEGF angiogenesis metastasis phenolic substance cell cycle