Kim, HJ Seo, SH Lee, BG Lee, YS 2024-01-21T04:37:15Z 2024-01-21T04:37:15Z 2021-09-03 2005-08 0032-0943 https://pubs.kist.re.kr/handle/201004/136267 Tyrosinase is a key enzyme in the production of melanins. Phytochemical studies of a Glycyrrhiza uralensis extract were performed by measuring the tyrosinase and melanin synthesis inhibitory activity. Glycyrrhisoflavone and glyasperin C were identified as tyrosinase inhibitors for the first time. Glyasperin C showed a stronger tyrosinase inhibitory activity (IC50 = 0.13 0.01 mu g/mL) than glabridin (IC50 = 0.25 +/- 0.01 mu g/mL) and a moderate inhibition of melanin production (17.65 +/- 8.8 % at 5 mu g/mL). Glycyrrhisoflavone showed a strong melanin synthesis inhibitory activity (63.73 +/- 6.8 % inhibition at 5 mu g/mL). These results suggest that glyasperin C and glycyrrhisoflavone could be promising candidates in the design of skin-whitening agents. English GEORG THIEME VERLAG KG FLAVONOIDS PIGMENTATION CONSTITUENTS ACID Identification of tyrosinase inhibitors from Glycyrrhiza uralensis Article 10.1055/s-2005-871232 1 PLANTA MEDICA, v.71, no.8, pp.785 - 787 PLANTA MEDICA 71 8 785 787 scie scopus 000231863000021 2-s2.0-24944508196 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article FLAVONOIDS PIGMENTATION CONSTITUENTS ACID Glycyrrhiza uralensis Leguminosae melanin Tyrosinase -whitening agents