Kim, K Kim, JH Kim, S Chung, H Choi, K Kwon, IC Park, JH Kim, YS Park, RW Kim, IS Jeong, SY 2024-01-21T05:01:54Z 2024-01-21T05:01:54Z 2021-09-03 2005-06 1598-5032 https://pubs.kist.re.kr/handle/201004/136434 This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH = 7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The BGC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section. English SPRINGER BLOCK-COPOLYMER MICELLES BEARING 5-BETA-CHOLANIC ACID INTEGRIN ALPHA(V)BETA(3) POLYMERIC MICELLES SOLUBLE CHITOSAN DRUG ADRIAMYCIN DELIVERY WATER ANGIOGENESIS Self-assembled nanoparticles of bile acid-modified glycol chitosans and their applications for cancer therapy Article 10.1007/BF03219048 1 MACROMOLECULAR RESEARCH, v.13, no.3, pp.167 - 175 MACROMOLECULAR RESEARCH 13 3 167 175 scie scopus kci ART000963283 000230276200001 2-s2.0-21644481747 Polymer Science Polymer Science Review BLOCK-COPOLYMER MICELLES BEARING 5-BETA-CHOLANIC ACID INTEGRIN ALPHA(V)BETA(3) POLYMERIC MICELLES SOLUBLE CHITOSAN DRUG ADRIAMYCIN DELIVERY WATER ANGIOGENESIS glycol chitosan nanoparticle EPR effect cancer therapy