Li, SP Kim, JH Park, MS Bahk, JY Chung, BC Kim, MO 2024-01-21T05:05:32Z 2024-01-21T05:05:32Z 2021-09-05 2005-05 0306-4522 https://pubs.kist.re.kr/handle/201004/136498 Prenatal ethanol exposure has various deleterious effects on neuronal development. As GABA(B) receptor is known to play an important role during the development of the CNS, we now focused on its mRNA expression pattern in the rat brain during the late gestational days (GD) from 15.5 to GD 21.5. Ethanol's effect was also observed from GD 11.5 to GD 21.5. GABA., receptor mRNA showed a high expression level in GD 15.5 and 19.5, while GABA(B2) receptor mRNA did in GD 15.5 and 21.5. The mRNAs levels depended on age and area during development. Ethanol exposure decreased GABA., receptor from GD 11.5 to GD 19.5 with slight increases in GD 21.5. The decreasing effects were area dependent, with the highest effects in the forebrain including cortex, whereas slight effects were observed in the midbrain and hindbrain. The present results suggest an important role of GABAB receptor in the effects of ethanol on prenatal brain developmental processes. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD SPONTANEOUS CALCIUM TRANSIENTS CENTRAL-NERVOUS-SYSTEM FETAL ALCOHOL SYNDROME CORTICAL-NEURONS IN-VITRO EXPOSURE ALTERS GROWTH CELLS MIGRATION CORTEX Ethanol modulates the expression of GABA(B) receptor mrnas in the prenatal rat brain in an age and area dependent manner Article 10.1016/j.neuroscience.2005.05.001 1 NEUROSCIENCE, v.134, no.3, pp.857 - 866 NEUROSCIENCE 134 3 857 866 scie scopus 000231491200014 2-s2.0-23644459513 Neurosciences Neurosciences & Neurology Article SPONTANEOUS CALCIUM TRANSIENTS CENTRAL-NERVOUS-SYSTEM FETAL ALCOHOL SYNDROME CORTICAL-NEURONS IN-VITRO EXPOSURE ALTERS GROWTH CELLS MIGRATION CORTEX development ethanol GABA(B) receptors mRNA brain area cortex