이병천 이상협 龜井 翼 眞柄 泰基 2024-01-21T05:35:07Z 2024-01-21T05:35:07Z 2021-09-06 2005-02 1225-7672 https://pubs.kist.re.kr/handle/201004/136766 The effects of chlorination on the elimination of three estrogenic chemicals such as 17β-estradiol (E2), nonylphenol (NP) and bis-phenol A (BPA) were investigated using yeast two-hybrid assay (YTA), estrogen receptor competition assay (ER-CA), and high-performance liquid chromatography/mass spectrometer (LC/MS). Results of YTA, ECA and the analysis of LC/MS indicated that the estrogenic activity of above mentioned three endocrine disruptors were significantly reduced as the result of chlorination. The decrease in estrogenic activity paralleled with decrease in estrogenic chemicals under the influence of free chlorine. One common characteristic of estrogenic chemicals is the presence of a phenolic ring. Considering that a phenolic ring is likely to undergo some sort of transformation in aqueous chlorination solution, the above mentioned results may be applied to the rest of the other estrogenic chemicals in natural waters. 대한상하수도학회 염소산화에 의한 에스트로겐성 화학물질의 활성저감 Decrease of Activity of Estrogenic Chemicals by Chlorination Article 2 상하수도학회지, v.19, no.1, pp.98 - 105 상하수도학회지 19 1 98 105 kci ART000934147 Estrogenic chemicals Yeast two-hybrid assay LC/MS Chlorination 에스트로겐성 화합물 효모 two-hybrid법 LC/MS 염소산화 Estrogenic chemicals Yeast two-hybrid assay LC/MS Chlorination