Lee, KS Kang, YK Yoo, KH Kim, DC Shin, KJ Paik, YS Kim, DJ 2024-01-21T05:38:54Z 2024-01-21T05:38:54Z 2021-09-03 2005-01-03 0960-894X https://pubs.kist.re.kr/handle/201004/136836 The synthesis of novel 1beta-methylcarbapenems 1a,b having sodium 5-(3- and 5-carboxylic acid)isoxazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. The selected sodium 3-carboxylic acid derivative la possessed excellent DHP-I stability and advanced pharmacokinetic parameters in comparison with 2 and meropenem. (C) 2004 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD Novel 1 beta-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt Article 10.1016/j.bmcl.2004.09.092 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.15, no.1, pp.231 - 234 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 1 231 234 scie scopus 000225773600044 2-s2.0-9644276816 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article