Jeong, SI Kim, BS Kang, SW Kwon, JH Lee, YM Kim, SH Kim, YH 2024-01-21T06:02:26Z 2024-01-21T06:02:26Z 2021-09-05 2004-12 0142-9612 https://pubs.kist.re.kr/handle/201004/136985 Tubular scaffolds were fabricated from very elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL, 50:50). The scaffolds were seeded with smooth muscle cells (SMCs) and implanted in nude mice to investigate the tissue compatibility and in vivo degradation behavior. Histological examination of all the implants with haematoxylin and eosin staining, masson trichrome staining, SM alpha-actin antibody, and CM-DiI labeling confirmed that the regular morphology and biofunction of the SMCs seeded and the expression of the vascular smooth muscle matrices in PLCL scaffolds. The implanted PLCL scaffolds displayed a slow degradation on time, where caprolactone units were faster degraded than lactide did. This could be explained by the fact that amorphous regions composed of mainly CL moieties degraded earlier than hard domains where most of the LA units were located. From these results, the scaffolds applied in this study were found to exhibit excellent tissue compatibility to SMCs and might be very useful for vascular tissue engineering. (C) 2004 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD SMOOTH-MUSCLE-CELLS EPSILON-CAPROLACTONE L-LACTIDE COPOLYMERS COLLAGEN BLOCK In vivo biocompatibilty and degradation behavior of elastic poly(L-lactide-co-epsilon-caprolactone) scaffolds Article 10.1016/j.biomaterials.2004.01.057 1 BIOMATERIALS, v.25, no.28, pp.5939 - 5946 BIOMATERIALS 25 28 5939 5946 scie scopus 000223208400004 2-s2.0-2942607678 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article SMOOTH-MUSCLE-CELLS EPSILON-CAPROLACTONE L-LACTIDE COPOLYMERS COLLAGEN BLOCK elastic PLCL scaffolds compatibility to smooth muscle cells biodegradation