Newton, PM Orr, CJ Wallace, MJ Kim, C Shin, HS Messing, RO 2024-01-21T06:06:48Z 2024-01-21T06:06:48Z 2021-09-05 2004-11-03 0270-6474 https://pubs.kist.re.kr/handle/201004/137066 N-type calcium channels are modulated by acute and chronic ethanol exposure in vitro at concentrations known to affect humans, but it is not known whether N-type channels are important for behavioral responses to ethanol in vivo. Here, we show that in mice lacking functional N-type calcium channels, voluntary ethanol consumption is reduced and place preference is developed only at a low dose of ethanol. The hypnotic effects of ethanol are also substantially diminished, whereas ethanol-induced ataxia is mildly increased. These results demonstrate that N-type calcium channels modulate acute responses to ethanol and are important mediators of ethanol reward and preference. English SOC NEUROSCIENCE CONDITIONED PLACE PREFERENCE CA2+ CHANNELS ALCOHOL-CONSUMPTION ALPHA(1B) SUBUNIT GABA RELEASE SENSITIVITY INHIBITION EXPRESSION RECEPTORS ANTAGONISTS Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice Article 10.1523/JNEUROSCI.3446-04.2004 1 JOURNAL OF NEUROSCIENCE, v.24, no.44, pp.9862 - 9869 JOURNAL OF NEUROSCIENCE 24 44 9862 9869 scie scopus 000224869600015 2-s2.0-7744237451 Neurosciences Neurosciences & Neurology Article CONDITIONED PLACE PREFERENCE CA2+ CHANNELS ALCOHOL-CONSUMPTION ALPHA(1B) SUBUNIT GABA RELEASE SENSITIVITY INHIBITION EXPRESSION RECEPTORS ANTAGONISTS alcoholism calcium channel conotoxin conditioned place preference ethanol preference knock-out