Schwarz, JM Lee, GA Park, S Noor, MA Lee, J Wen, M Lo, JC Mulligan, K Schambelan, M Grunfeld, C 2024-01-21T06:31:36Z 2024-01-21T06:31:36Z 2021-09-01 2004-09-03 0269-9370 https://pubs.kist.re.kr/handle/201004/137239 In the absence of HIV infection, changes in adipose tissue and lipid levels, HIV protease inhibitor therapy increases fasting glucose levels, suggestive of hepatic insulin resistance. After 4 weeks of indinavir treatment in nine HIV-negative healthy men, fasting glucose production and glycogenolysis were significantly increased. During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production. English LIPPINCOTT WILLIAMS & WILKINS INSULIN HUMANS Indinavir increases glucose production in healthy HIV-negative men Article 10.1097/00002030-200409030-00017 1 AIDS, v.18, no.13, pp.1852 - 1854 AIDS 18 13 1852 1854 scie scopus 000223667900017 Immunology Infectious Diseases Virology Immunology Infectious Diseases Virology Article INSULIN HUMANS indinavir glucose production HIV