Kim, KM
Paeng, KJ
Hahm, JR
Kim, DR
Chung, BC
2024-01-21T06:33:31Z
2024-01-21T06:33:31Z
2021-09-05
2004-09
0952-3278
https://pubs.kist.re.kr/handle/201004/137274
In this study, we investigate how oxidative stress alters the urinary F-2-isoprostanes' level and we examine the correlation between 8-isoPGF(2alpha) and thyroid hormones in female patients with Graves' hyperthyroidism. We quantitatively determined the concentrations of urinary F-2-isoprostanes using gas chromatography-mass spectrometry in the selected ion-monitoring mode. We recruited individuals in the following three groups of subjects for this study: (1) female hyperthyroidism patients (n = 14, 21-71 years), (2) female hypothyroidism patients (n = 16, 16-66 years), and (3) female age-matched normal controls (n = 10, 20-61 years). The average concentration of 8-iso prostaglandin F-2alpha (8-isoPGF(2alpha)) in hyperthyroidism patients was significantly higher than that in the healthy controls (P < 0.05). The concentration of 8-isoPGF(2alpha) in hypothyroidism patients was similar to that in normal controls. Although the level of 8-isoPGF(2alpha) in two of the patients was slightly elevated, the P value was not significant (NS). Our data suggest that the increased level of urinary 8-isoPGF(2alpha) may reflect possible oxidation injuries in hyperthyroidism patients due to the high level of thyroid hormones. Therefore, the elevated 8-isoPGF(2alpha) in patients could be used as an important biomarker for hyperthyroidism disease. (C) 2004 Published by Elsevier Ltd.
English
ELSEVIER SCI LTD
LOW-DENSITY-LIPOPROTEIN
LIPID-PEROXIDATION
OXIDATIVE STRESS
THYROID-HORMONES
IN-VIVO
SKELETAL-MUSCLE
RAT-LIVER
F-2-ISOPROSTANES
HYPOTHYROIDISM
SMOKERS
Elevated urinary 8-isoprostaglandin F-2 alpha in females with Graves' hyperthyroidism
Article
10.1016/j.plefa.2004.01.005
1
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v.71, no.3, pp.143 - 147
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
71
3
143
147
scie
scopus
000223001600002
2-s2.0-3142598663
Biochemistry & Molecular Biology
Cell Biology
Endocrinology & Metabolism
Biochemistry & Molecular Biology
Cell Biology
Endocrinology & Metabolism
Article
LOW-DENSITY-LIPOPROTEIN
LIPID-PEROXIDATION
OXIDATIVE STRESS
THYROID-HORMONES
IN-VIVO
SKELETAL-MUSCLE
RAT-LIVER
F-2-ISOPROSTANES
HYPOTHYROIDISM
SMOKERS
urine
hyperthyrodism
8-isoprostaglandin