Kim, KM
Jung, BH
Paeng, KJ
Kim, I
Chung, BC
2024-01-21T06:39:53Z
2024-01-21T06:39:53Z
2021-09-05
2004-07-30
0361-9230
https://pubs.kist.re.kr/handle/201004/137390
Isoprostanes, novel markers of oxidative injury, are generated by the free radical-mediated peroxidation of arachidonic acid (AA). They are thought to be important in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Using gas chromatography-mass spectrometry (GC-MS), we investigated the alteration of urinary F-2-isoprostanes in AD patients compared to that of healthy subjects. Our results show that the levels of urinary F-2-isoprostanes, sum of the prostaglandin F-2alpha isomer; prostaglandin F-2alpha (PGF(2alpha)), prostaglandin F-2beta (PGF(2beta)), and 8-isoprostaglandin F-2alpha (8-isoPGF(2alpha)), significantly increased in AD patients (P < 0.05). The concentration of urinary 8-isoPGF(2alpha), one of the biomarkers of oxidative stress, was not significantly different between 34 AD patients and 20 age-matched controls (P > 0.05). The PGF(2alpha), formed by endoperoxide reductase from PGH(2), was significantly increased in AD patients, when compared with the levels of the normal controls (P < 0.05). The PGF(2alpha), an enzymatic product of arachidonic acid, may affect the pathogenesis of AD. In addition, urinary F-2-isoprostanes can play an important role as a biomarker in AD. (C) 2004 Elsevier Inc. All rights reserved.
English
PERGAMON-ELSEVIER SCIENCE LTD
LIPID-PEROXIDATION
OXIDATIVE STRESS
DIETARY-INTAKE
IN-VIVO
RISK
Increased urinary F-2-isoprostanes levels in the patients with Alzheimer's disease
Article
10.1016/j.brainresbull.2004.04.016
1
BRAIN RESEARCH BULLETIN, v.64, no.1, pp.47 - 51
BRAIN RESEARCH BULLETIN
64
1
47
51
scie
scopus
000223282700007
2-s2.0-3242690571
Neurosciences
Neurosciences & Neurology
Article
LIPID-PEROXIDATION
OXIDATIVE STRESS
DIETARY-INTAKE
IN-VIVO
RISK
F-2-isoprostanes
Alzheimer&apos
s disease
oxidative stress
gas chromatography-mass spectrometry