Zhang, YH Park, JH Lee, SG 2024-01-21T06:40:00Z 2024-01-21T06:40:00Z 2022-01-10 2004-07-26 0957-4166 https://pubs.kist.re.kr/handle/201004/137392 It has been demonstrated for the first time that Rh(I)-catalyzed asymmetric hydrogenation of cyclic beta-enamino acid derivatives I using chiral bisphosphines could be a highly efficient synthetic method for optically active homoproline derivatives. The enantioselectivity and conversion yield were largely dependent upon the chiral ligand. Using the Me-BDPMI forming a seven-membered metal chelate, the N-acetylated beta-enamino acid methyl ester la was hydrogenated to give optically active homoproline derivative 2a with 100% conversion and 96% ee. (C) 2004 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD BETA-AMINO ACIDS HIGHLY ENANTIOSELECTIVE HYDROGENATION RHODIUM-CATALYZED HYDROGENATION SUBSTITUTED BETA-(ACYLAMINO)ACRYLATES DIASTEREOSELECTIVE SYNTHESIS RECEPTOR ANTAGONISTS ESTERS ENAMINOESTERS CYCLIZATION ALKYLATION Asymmetric synthesis of homoproline derivatives via Rh(I)catalyzed hydrogenation using chiral bisphosphines as ligands Article 10.1016/j.tetasy.2004.04.014 1 TETRAHEDRON-ASYMMETRY, v.15, no.14, pp.2209 - 2212 TETRAHEDRON-ASYMMETRY 15 14 2209 2212 scie scopus 000223219400019 2-s2.0-3843097462 Chemistry, Inorganic & Nuclear Chemistry, Organic Chemistry, Physical Chemistry Article BETA-AMINO ACIDS HIGHLY ENANTIOSELECTIVE HYDROGENATION RHODIUM-CATALYZED HYDROGENATION SUBSTITUTED BETA-(ACYLAMINO)ACRYLATES DIASTEREOSELECTIVE SYNTHESIS RECEPTOR ANTAGONISTS ESTERS ENAMINOESTERS CYCLIZATION ALKYLATION chiral phosphine asymmetric catalysis hydrogenation