Yoon, SH Seger, R Choi, EJ Yoo, YS 2024-01-21T06:42:48Z 2024-01-21T06:42:48Z 2021-09-05 2004-07 0006-2979 https://pubs.kist.re.kr/handle/201004/137444 SB203580 is a p38 MAPK inhibitor that has been implicated in the activation of c-Raf. This study shows that the addition of SB203580 to PC12 cells causes the sustained activation of B-Raf but not of ERK. The addition of SB203580 prolonged the transient activation of both B-Raf and ERK by EGF alone. No significant change was detected in MAPKAPK-2 activity at low concentrations of S13203580, which induced neurite outgrowth in the EGF-stimulated PC 12 cells. Therefore, these results indicate that SB203580 influences not only c-Raf as previously reported, but can also induce the activation of B-Raf, which in conjunction with EGF causes the sustained activation of ERK and differentiation in PC12 cells. English MAIK NAUKA/INTERPERIODICA/SPRINGER SIGNAL-REGULATED KINASE NERVE GROWTH-FACTOR PROTEIN-KINASE P38 MAPK SPECIFICITY INHIBITOR INDUCTION PATHWAY SERINE RAP1 SB203580 induces prolonged B-Raf activation and promotes neuronal differentiation upon EGF treatment of PC12 cells Article 10.1023/B:BIRY.0000040206.71415.6f 1 BIOCHEMISTRY-MOSCOW, v.69, no.7, pp.799 - 805 BIOCHEMISTRY-MOSCOW 69 7 799 805 scie scopus 000223441800013 2-s2.0-4444255796 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article SIGNAL-REGULATED KINASE NERVE GROWTH-FACTOR PROTEIN-KINASE P38 MAPK SPECIFICITY INHIBITOR INDUCTION PATHWAY SERINE RAP1 B-Raf SB203580 ERK neurite outgrowth nuclear translocation PC12 cells