Lim, SS Shin, KH Jung, SH Shin, KJ Kim, DC Park, SW Shin, HK Keum, SR 2024-01-21T06:43:33Z 2024-01-21T06:43:33Z 2021-09-02 2004-07 0022-3573 https://pubs.kist.re.kr/handle/201004/137458 The therapeutic potential of aldose reductase inhibitors for the prevention of the secondary complications of diabetes has been extensively reported. On the other hand, the hyperaggregability of platelets in diabetic patients has also been reported as a cause of chronic diabetic complications. The purpose of this study was to develop new compounds with these dual effects from pyridyloxy- or phenoxylphenoxyalkanate synthesized derivatives and examine the effect of their structure-activity relationships on the inhibition of rat lens aldose reductase (RLAR) as well as on platelet aggregation. 2-[4-(2,6-dichloro-3-methyl-phenoxy)-3-nitro-phenoxyl-propionic acid (3) exhibited the most potent inhibitory effect (IC50 = 3.0 +/- 0.21 muM), comparable to tetramethylene glutaric acid (IC50 = 6.1 +/- 0.2 muM), which is used as a positive control on RLAR, and showed potent inhibitory activities on rat platelet aggregation induced by ADP and collagen (IC50 = 0.093 +/- 0.01 and 0.032 +/- 0.01 muM, respectively) comparable with aspirin (IC50 = 0.15 +/- 0.05 and 0.047 +/- 0.01 muM, respectively), used as a positive control. English WILEY PHENOXYALKANOIC ACID-DERIVATIVES DIABETIC COMPLICATIONS ANALGESIC ACTIVITIES SORBITOL Inhibitory effect of pyridyloxy- or phenoxylphenoxyalkanate derivatives on rat lens aldose reductase and rat platelet aggregation Article 10.1211/0022357023664 1 JOURNAL OF PHARMACY AND PHARMACOLOGY, v.56, no.7, pp.941 - 945 JOURNAL OF PHARMACY AND PHARMACOLOGY 56 7 941 945 scie scopus 000222580300016 2-s2.0-3042730809 Pharmacology & Pharmacy Pharmacology & Pharmacy Article PHENOXYALKANOIC ACID-DERIVATIVES DIABETIC COMPLICATIONS ANALGESIC ACTIVITIES SORBITOL