Kim, SH Song, YS Kim, SK Kim, BC Lim, CJ Park, EH 2024-01-21T06:43:59Z 2024-01-21T06:43:59Z 2021-09-02 2004-07 0378-8741 https://pubs.kist.re.kr/handle/201004/137466 This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subtraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subtraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved. English ELSEVIER IRELAND LTD ANGIOGENESIS INHIBITION POLYSACCHARIDE GROWTH Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus Article 10.1016/j.jep.2004.03.048 1 JOURNAL OF ETHNOPHARMACOLOGY, v.93, no.1, pp.141 - 146 JOURNAL OF ETHNOPHARMACOLOGY 93 1 141 146 scie scopus 000222249000023 2-s2.0-2942624164 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article ANGIOGENESIS INHIBITION POLYSACCHARIDE GROWTH Phellinus linteus anti-inflammatory antinociceptive anti-angiogenic chorioallantoic membrane ear edema folk medicine