Lee, S Jung, SH Lee, YS Yamada, M Kim, BK Ohuchi, K Shin, KH 2024-01-21T07:04:15Z 2024-01-21T07:04:15Z 2021-09-02 2004-06 0253-6269 https://pubs.kist.re.kr/handle/201004/137557 The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E-2 (PGE(2)) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). Hyperin was isolated as an active principle from the ethyl acetate fraction. It suppressed not only PGE2 production but also nitric oxide (NO) production in vitro in a concentration dependent manner, their IC50, being 24.3 and 32.9 muM, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo. English PHARMACEUTICAL SOCIETY KOREA INHIBITION STIMULATION MACROPHAGES PROTEIN Antiinflammatory activity of hyperin from Acanthopanax chiisanensis roots Article 10.1007/BF02980162 1 ARCHIVES OF PHARMACAL RESEARCH, v.27, no.6, pp.628 - 632 ARCHIVES OF PHARMACAL RESEARCH 27 6 628 632 scie scopus kci 000222363000010 2-s2.0-21644443814 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article INHIBITION STIMULATION MACROPHAGES PROTEIN Acanthopanax chiisanensis Araliaceae hyperin anti-inflammatory activity