Hahn, HG Oh, HS Cheon, SH Oak, MH Kim, YR Kim, KM 2024-01-21T07:07:26Z 2024-01-21T07:07:26Z 2021-09-02 2004-05 0253-6269 https://pubs.kist.re.kr/handle/201004/137616 An allergic reaction ensues after antigen binds to mast cell or basophil high affinity IgE receptor, FcepsilonRI, resulting in degranulation of various inflammatory mediators that produce various allergic symptoms. In this study, i) we isolated the active component for the inhibition of mast cell degranulation from the extract of leaves of Castanea crenata and identified it as quercetin; ii) we established the total synthesis procedure of quercetin; iii) using quercetin as positive control, we excavated some lead compounds that possess inhibitory activities for mast cell degranulation by screening the chemical libraries of 1,3-oxazolidine derivatives prepared by solid phase combinatorial chemistry. Some of 1,3-oxazolidine compounds possessing acetyl and 3',4'-dichlorophenyl group displayed strong inhibitory activities on FcepsilonRI-mediated mast cell degranulation, suggesting that they can be used as lead compounds for the development of anti-allergic agents. English PHARMACEUTICAL SOC KOREA ANTIALLERGIC ACTIONS RECEPTOR ANTIGEN RELEASE Excavation of lead compounds that inhibit mast cell degranulation by combinatorial chemistry and activity-guided Article 10.1007/BF02980125 1 ARCHIVES OF PHARMACAL RESEARCH, v.27, no.5, pp.518 - 523 ARCHIVES OF PHARMACAL RESEARCH 27 5 518 523 scie scopus kci ART000936172 000221753400009 2-s2.0-16544365647 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article ANTIALLERGIC ACTIONS RECEPTOR ANTIGEN RELEASE Castanea crenata quercetin mast cell degranulation combinatorial chemistry 1,3-oxazolidines allergy