김주환 신경식 김용국 김태송 김상식 주병권 2024-01-21T07:12:58Z 2024-01-21T07:12:58Z 2021-09-06 2004-04 1226-7945 https://pubs.kist.re.kr/handle/201004/137717 We fabricated photo-sensor for fluorescence detection in LOC. LOC is high throughput screening system. Our LOC screens biochemical reaction of protein using the immunoassay, and converts biochemical reaction into electrical signal using LIF(Laser Induced Fluorescence) detection method. Protein is labeled with rhodamine intercalating dye and finger PIN photodiode is used as photo-sensor. We measured fluorescence emission of rhodamine dye and analyzed tendency of fluorescence detection, according to photo-sensor size, light intensity, and rhodamine concentration. Detection current was almost linearly proportional to two parameters, intensity and concentration, and was inversely proportional to photo-sensor size. Integrated LOC consists of optical-filter deposited photo-sensor and PDMS microchannel detected 50 [pg/㎕] rhodamine. For integrated LOC including light source, we used green LED as the light source and measured emitted fluorescence. 한국전기전자재료학회 집적화된 Lab-On-a Chip을 위한 광센서의 제작 및 특성 평가 Development of Photo-sensor for Integrated Lab-On-a-Chip Article 2 전기전자재료학회논문지, v.17, no.4, pp.404 - 409 전기전자재료학회논문지 17 4 404 409 kci ART000934197 Lab-On-a-Chip Photo-sensor Fluorescence detection Integration LED Lab-On-a-Chip Photo-sensor Fluorescence detection Integration LED