An, JJ Bae, MH Cho, SR Lee, SH Choi, SH Lee, BH Shin, HS Kim, YN Park, KW Borrelli, E Baik, JH 2024-01-21T07:14:06Z 2024-01-21T07:14:06Z 2021-09-02 2004-04 1044-7431 https://pubs.kist.re.kr/handle/201004/137738 The levels of glutamic acid decarboxylase (GAD) were strongly increased in the cortex and the striatum in dopamine D2 receptors null (D2R-/-) mice, which show a significant locomotor impairment. In this study, the effects of different GABAergic drugs on locomotor,activity were analyzed in D2R-/- mice. After administering muscimol (1 mg/kg), a GABA(A) receptor agonist, the D2R-/- mice showed increased locomotor activity up to 200%. When the muscimol dose was increased (4-6 mg/kg), the D2R-/- mice exhibited seizure-like behavior, and the electroencephalographic (EEG) recordings during these behaviors showed a high amplitude rhythmic epileptiform activity in these mice. In situ hybridization showed that after injecting muscimol in the D2R-/- mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation. These results suggest that the absence of D2R alters the GABAergic neurotransmission, specifically on GABA(A)-receptor mediated signaling, and stimulating the GABA(A) receptor can reverse the dysfunction of GABAergic inhibition in the motor circuits in the basal ganglia. (C) 2004 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE GENE-EXPRESSION BASAL GANGLIA STRIATOPALLIDAL NEURONS LOCOMOTOR IMPAIRMENT SUBTHALAMIC NEURONS GABA(A) RECEPTORS RAT HIPPOCAMPUS PARS RETICULATA IN-VITRO NGFI-A Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors Article 10.1016/j.mcn.2003.12.010 1 MOLECULAR AND CELLULAR NEUROSCIENCE, v.25, no.4, pp.732 - 741 MOLECULAR AND CELLULAR NEUROSCIENCE 25 4 732 741 scie scopus 000220852400016 2-s2.0-11144356288 Neurosciences Neurosciences & Neurology Article GENE-EXPRESSION BASAL GANGLIA STRIATOPALLIDAL NEURONS LOCOMOTOR IMPAIRMENT SUBTHALAMIC NEURONS GABA(A) RECEPTORS RAT HIPPOCAMPUS PARS RETICULATA IN-VITRO NGFI-A