Jung, S.H. Kang, S.S. Shin, K.H. Kim, Y.S. 2024-01-21T07:37:01Z 2024-01-21T07:37:01Z 2021-09-02 2004-02 1226-3907 https://pubs.kist.re.kr/handle/201004/137884 Aldose reductase (AR), the key enzyme of the polyol pathway, is known to play important roles in the diabetic complications. The inhibitors of AR, therefore, would be potential agents for the prevention of diabetic complications. In order to clarify the structural requirements of flavonoids for aldose reductase inhibitory activity, thirty flavonoids were examined. Among the thirty flavonoids, flavonols such as quercetin (5), reyneutrin (7), quercitrin (9), isoquercitrin (11), and avicularin (14) were found to exhibit much stronger AR inhibition. Lonicerin (10), amentoflavone (27) and sophoraflavanone B (30) were also showed strong inhibitory activity. Especially, quercitrin and reyneutrin exhibited the most inhibitory potency on rat lens (RL) AR. The results suggested that flavonol having the 7-hydroxyl and/or catechol moiety at the B ring exhibit strong activity. In additon, flavonols having 3-O-monosaccharide also showed stronger inhibition than free flavonols at the 3-position. These results suggested that quercitrin and reyneutrin are attributed to be the promising compounds for the prevention and/or treatment of diabetic complications. English aldehyde reductase aldose reductase inhibitor amentoflavone avicularine flavonoid flavonol derivative isoquercitrin lonicerin monosaccharide quercetin quercitrin reyneutrin sophoraflavanone unclassified drug article diabetes mellitus diabetic neuropathy diabetic retinopathy drug activity drug potency drug structure enzyme activity enzyme inhibition enzyme mechanism lens nonhuman rat structure activity relation Inhibitory Effects of Naturally Occurring Flavonoids on Rat Lens Aldose Reductase Article 1 Natural Product Sciences, v.10, no.1, pp.35 - 39 Natural Product Sciences 10 1 35 39 scopus kci other 2-s2.0-1542318408 Article aldehyde reductase aldose reductase inhibitor amentoflavone avicularine flavonoid flavonol derivative isoquercitrin lonicerin monosaccharide quercetin quercitrin reyneutrin sophoraflavanone unclassified drug article diabetes mellitus diabetic neuropathy diabetic retinopathy drug activity drug potency drug structure enzyme activity enzyme inhibition enzyme mechanism lens nonhuman rat structure activity relation Aldose reductase Diabetic complications Quercitrin Reyneutrin