Jung, BH Bai, SW Chung, BC 2024-01-21T07:41:50Z 2024-01-21T07:41:50Z 2021-09-02 2004-01 0020-7292 https://pubs.kist.re.kr/handle/201004/137971 Objectives: To study the effect of endogenous steroids on the presence of uterine leiomyomas. Methods: Urine samples of 27 premenopausal women with leiomyomas and 25 age-matched healthy premenopausal women were collected. The concentration of estrogens and androgens in the urine samples of the two groups were determined using a gas chromatography mass spectrometer and the two groups were compared. To study metabolic changes in patients indirectly, the concentration ratios of precursor metabolite to product metabolite of the two groups were also compared. Results: Urinary concentrations of 17beta-estradiol, 5-androstene-3beta, 16beta, 17beta, triol, 11-keto-ethiocholanolone, 11,6-hydroxy-androsterone, 11beta-hydroxy-etiocholanolone, THS, THA, THE, alpha-cortol and beta-cortol were significantly higher in patients than in controls. The concentration ratios of 17beta-estradiol/estrone and 11/beta-hydroxyethiocholanolone/11beta-hydroxy-androsterone increased in patients. Conclusions: The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients' metabolism of steroids. (C) 2003 International Federation of Gynecology and Obstetrics. Published by Elsevier Science Ireland Ltd. All rights reserved. English WILEY PROGESTERONE-RECEPTOR CONTENT HORMONE AGONIST LEUPROLIDE HUMAN MYOMETRIUM GENE-EXPRESSION ESTROGEN Endogenous urinary steroids in premenopausal women with uterine leiomyomas Article 10.1016/S0020-7292(03)00336-9 1 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, v.84, no.1, pp.55 - 60 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 84 1 55 60 scie scopus 000188228000009 2-s2.0-0346059530 Obstetrics & Gynecology Obstetrics & Gynecology Article PROGESTERONE-RECEPTOR CONTENT HORMONE AGONIST LEUPROLIDE HUMAN MYOMETRIUM GENE-EXPRESSION ESTROGEN leiomyoma steroids estrogens androgens urinary concentration